Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
ANALYSIS OF ESTROGEN–MEDIATED SIGNALING REVEALS A NOVEL EPIGENETIC TARGET FOR ENDOCRINE THERAPY-RESISTANT BREAST CANCER TREATMENT
Vol 32, Issue 4S1, 2018
Abstract
Estrogen Receptor alpha (ERa) is the master regulator of estrogen signaling in hormone-responsivebreast cancer (BC) and it is the primary target of specific anticancer therapies. Nevertheless, thedevelopment of resistance to treatment represents the key problem in clinical management of patientsaffected by this disease. We reported that the epigenetic writer DOT1L (DOT1-Like Histone LysineMethyltransferase) associates with ERa [1] as part of a multiprotein chromatin regulatory complex. Weinvestigated here the role of this enzyme in estrogen signaling to the genome in luminal-like BC cells.
References
Supporting Agencies
Copyright (c) 2018 G. GIURATO, G. NASSA, A. SALVATI, R. TARALLO, F. RIZZO, V. GIGANTINO, L. MAUTONE, T.A. NYMAN, W. WEISZ
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy