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The role of periodontal bacteria, Porphyromonas Gingivalis, in Alzheimers disease pathogenesis and aggravation: a review
Vol 35, Issue 3S1, 2021
Abstract
The aim of this study was to establish the role of Porphyromonas gingivalis in Alzheimers disease. An electronic search of publications was established from three electronic databases: Cochrane, PubMed and Web of Science. The search strategy used a combination of controlled vocabulary and free-text words. Inclusion and exclusion criteria were defined by the authors before the start of the study. The inclusion criteria were: all studies published in English language; in vitro analysis; in vivo on animals and postmortem biopsies on humans; studies analyzing the correlation between periodontal disease and Alzheimer. The search resulted in 262 titles. Only 9 articles were included in the quantitative analysis. An inflammatory status in the oral cavity might be connect to a brain degeneration syndrome such as dementia and AD. However, a strictly connection is still not evincible. More trials are recommended in order to investigate the role of periodontal bacteria and Porphyromonas gingivalis in AD pathogenesis and aggravation.
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Copyright (c) 2021 C Lorenzi, N Bianchi, A Pinto, V Mazzetti, C Arcuri
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy