Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
COVID 19 and autoimmune blistering diseases: is there a link between epidermolysis bullosa acquisita and SARS-CoV-2?
Vol 36, Issue 2S4, 2022
Abstract
The blistering disease Epidermolysis bullosa acquisita is a genetic/autoimmune disorder derivingfrom alterations of the human protein Collagen alpha-1(VII) chain (CO7A1). Exposure to severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2) promotes a wide variety of autoimmune diseases andmight be a risk factor for Epidermolysis bullosa acquisita; in order to further our understanding of thelink between this blistering disease and SARS-CoV-2, this study analyzes the peptide-sharing betweenCO7A1 and SARS-CoV-2 proteome. Results indicate a high level of molecular mimicry between CO7A1and SARS-CoV-2 and hCoV-229E, and hCoV-NL63, thus suggesting a potential role of COVID-19 as arisk factor for Epidermolysis bullosa acquisita.
Keywords
References
Supporting Agencies
Copyright (c) 2022 R. Grassi, M. Contaldo, A. Romano, G.M. Nardi, R. Borgia, R. Serpico, M. Petruzzi
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy