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Oral Microbioma and Pemphigus vulgaris
Vol 36, Issue 2S4, 2022
Abstract
OBJECTIVE: Pemphigus Vulgaris (PV) is a mucocutaneous autoimmune disease mediated byautoantibodies that often affects oral mucosa. However, little is known about the connection between oralinfections and PV. The present study addresses the hypothesis that immune responses following bacterialinfections may cross-react with PV autoantigens, thus providing the pathogenic stimulus, eventuallyleading to clinical manifestations.METHODS: Available proteomic resources and immunologic data were explored. Searching for commonpeptides that underlie immune cross-reactions, the analyses focused on pathogenic oral bacteria and PVautoantigens, i.e., Desmoglein-3 (Dsg3).RESULTS: It was found that the analysed bacteria share numerous immunoreactive heptapeptidesequences with Dsg3.CONCLUSION: These data seem to support the hypothesis that the oral microbiome may alsocontribute to the pathogenesis of PV, with important implications for the treatment of this disease.
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Copyright (c) 2022 M. Petruzzi, A. Romano, A. Baroni, R. Borgia, A. Fusco, G. Donnarumma, M. Contaldo, R. Serpico
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy