Peptide sharing between SARS-CoV-2 and Bullous pemphigoid 180

A. Lucchese; D. Di Stasio; R. Borgia; M. Scivetti; M. Petruzzi

doi:10.23812/j.biol.regul.homeost.agents.202236.2S4.3

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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Peptide sharing between SARS-CoV-2 and Bullous pemphigoid 180

A. Lucchese, D. Di Stasio, R. Borgia, M. Scivetti, M. Petruzzi

Article ID: 6311
Vol 36, Issue 2S4, 2022

DOI: https://doi.org/10.23812/j.biol.regul.homeost.agents.202236.2S4.3

Received: 9 May 2022; Accepted: 9 May 2022; Available online: 9 May 2022; Issue release: 9 May 2022

Abstract

Bullous pemphigoid (BP) has been repeatedly reported to occur following exposure to the severeacute respiratory syndrome coronavirus 2 (SARS-CoV-2). This study analyzes the molecular mimicrybetween the 180 kDa bullous pemphigoid antigen 2 (BP180) and the SARS-CoV-2 proteome to further ourunderstanding of the molecular link between the BP and the SARS-CoV-2 infection. Results indicate a highdegree of molecular mimicry between BP180, SARS-CoV-2, hCoV-229E and hCoV-NL63.

Keywords

Bullous pemphigoid;BP180;SARS-Cov-2;Covid-19;autoimmunity;molecular mimicry;cross-reactivity

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Medical Genetics, University of Torino Medical School, Italy

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