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COVID 19 and Pemphigus vulgaris: a potential correlation
Vol 36, Issue 2S4, 2022
Abstract
Autoimmune blistering diseases have been associated with exposure to the severe acute respiratorysyndrome coronavirus 2 (SARS-CoV-2). In addition, oropharyngeal Pemphigus vulgaris appears to beassociated with the coronavirus. In order to understand the molecular basis linking SARS-CoV-2 andPemphigus vulgaris, this study explores the molecular mimicry hypothesis and analyzes the peptidesharing between the Pemphigus vulgaris autoantigen, i.e., Desmoglein 3 (Dsg-3), and the SARS-CoV-2proteome. Results indicate a low molecular mimicry level, still immunologically significant, betweenSARS-CoV-2 and Dsg-3.
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Supporting Agencies
Copyright (c) 2022 M. Petruzzi, A. Romano, F. Fiori, R. Borgia, M. Contaldo, R. Serpico
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy