Oro-facial pain in Chiari type 1 malformation

Abstract

The symptom of facial pain is one of the most common reasons for referral to a dental centre or an oralmaxillofacial treatment centre. Orofacial pain is a common symptom with many causes. However, oro-facialpain is rarely the only symptom of Chiari type 1 malformation (CM1), a disease characterized by an anatomicaldefect at the base of the skull where the cerebellum and the spinal cord herniate through the foramenmagnum into the cervical spinal canal. Approximately 20% of patients with CM1 may also experience facialhypesthesia, trigeminal or glossopharyngeal neuralgia, paralysis of the vocal cords, soft palate weakness. Inthe literature, proposed mechanisms to explain the trigeminal neuralgia and CM1 correlation are vascularcompression at the nerve root entry zone, which could be affected by hydrocephalus or anatomic factorsrelated to the CM1, demyelination, micro-ischemic changes and direct brainstem compression. However,further investigation on the mechanisms involved in orofacial pain in patients with CM1 is needed.