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Salivary markers quantification of oxidative stress in patients with periodontitis, before and after intensive periodontal treatment: a one-blinded, randomized, clinical trial
Vol 36, Issue 2S3, 2022
Abstract
AIM: Periodontitis is one of the most common inflammatory and infectious diseases, significantly associatedwith circulating levels of oxidative stress biomarkers. A network of interacting molecular pathways comprisingproinflammatory mediators and reactive oxygen species (ROS) are involved in the progression of periodontitis. Theaim of the trial was to determine the effects of intensive periodontal treatment on the salivary levels of oxidativestress in patients with moderate periodontitis.MATERIALS AND METHODS: A randomized, one-blinded, controlled clinical trial was conducted with 3months of follow-up. A total of 58 patients were included in the study and randomized to receive intensive periodontaltreatment (Group Test) or conventional adult prophylaxis (Group Control). Salivary samples for determination oftotal antioxidant status (TAS), total oxidant status (TOS), nitric oxide (NO), myeloperoxidase (MPO), glutathione(GSH), malondialdehyde (MDA) levels, and 8-hydroxy-2’deoxyguanosine (X8-OHdG) concentrations werecollected from each patient prior to the periodontal treatment and at 3 months after the therapy.RESULTS: A significantly decreased NO, and MDA levels were registered in the Test Group compared to theControl Group (p<.0001), and the concentration of GSH was found to be significantly increased in the test groupcompared to the control group.CONCLUSION: Intensive periodontal treatment mitigates salivary oxidative stress in patients with moderateperiodontitis.
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Supporting Agencies
Copyright (c) 2022 I. Converti, A. Palermo, A. Mancini, M.E. Maggiore, G.M. Tartaglia, E. Ferrara, F. Lorusso, A. Scarano, I.R. Bordea, C. Sforza, C. Maspero, M. Farronato, M.G. Cagetti, A. Patano, S. Ceci, A. Corriero, D. Hazballa, A. Gnoni, E. Gentile, A. Semjonova, K. Ferati, A. Bexheti-Ferati, M.F. Coscia, R. Del Prete, E. Xhajanka, AT. Pustina-Krasniqi, G. Malcangi
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Medical Genetics, University of Torino Medical School, Italy

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy