AIM: Chemical exogen acids effect can be considered in terms of the loss of hard tissue of teeth or potentialloss. When the remineralization does not antagonize the demineralization, the dissolution of hard tissuesarises. Significant among physical processes is degeneration in enamel structure due to the chemical processesof acidification and alkalinization. There are also several underlying determinants of enamel erosion. Theenamel erosion induced by chemical exogen acids causes the dissolution of the hard tissues of teeth. The aimof this study was to analyze the erosive effect of three different soft drinks on the enamel surface and thepotential remineralizing effect after applying casein phosphopeptide-amorphic calcium phosphate.MATERIALS AND METHODS: Fifteen human third molar teeth specimens were analyzed to assessthe effects of the topical cream containing 10% w/w casein phosphopeptide-amorphic calcium phosphate(CPP-ACP) nanocomplexes on enamel teeth lesions. Morphological characterization of teeth was performedusing Environmental Scanning Electron Microscope (ESEM). In addition, the surface of specimens wasexamined before and after immersion into three recipients containing three different soft drinks and after theremineralization process for comparison.RESULTS: Environmental Scanning Electron Microscopy analysis showed enamel morphology alterationsafter acidic soft drink exposure and superficially repair of teeth enamel after remineralizing treatment.CONCLUSION: This in vitro study demonstrated that the casein phosphopeptide-amorphic calciumphosphate treatment was effective in remineralizing demineralized subsurface lesion enamel in vitro afterhaving caused alterations by exogen acids.