The role of cytokines in pulp inflammation

A. Kokkas, A. Goulas, C. Stavrianos, G. Anogianakis

Article ID: 6228
Vol 25, Issue 3, 2011
DOI: https://doi.org/10.54517/jbrha6228
Received: 9 October 2011; Accepted: 9 October 2011; Available online: 9 October 2011; Issue release: 9 October 2011

Abstract

Pulpitis is a typical inflammatory disease of dental pulp, characterized by the local accumulation of inflammatory mediators, including cytokines and chemokines. In addition to serving as intercellular messengers mediating the inflammatory response, cytokines and chemokines induce the expression and stimulate the activity of molecular and cellular agents which participate actively in destructive and reparative processes in the pulp. It is the balance between these processes which eventually determines the extent of pulp inflammation and the viability of the affected tooth. Over the last decade, a number of studies have attempted to correlate cytokine gene expression in the pulp with various stages of inflammation, with possible diagnostic applications in mind. A small survey of relevant information is presented in this paper


Keywords

pulp inflammation;cytokines


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