Beneficial nutraceutical modulation of cerebral erythropoietin expression and oxidative stress: an experimental study

S. Sedriep, X. Xia, F. Marotta, L. Zhou, H. Yadav, H. Yang, V. Soresi, R. Catanzaro, K. Zhong, A. Polimeni, D.H. Chui

Article ID: 6213
Vol 25, Issue 2, 2011
DOI: https://doi.org/10.54517/jbrha6213
Received: 9 July 2011; Accepted: 9 July 2011; Available online: 9 July 2011; Issue release: 9 July 2011

Abstract

The main object of this study is to examine the effect of Klamin®, a nutraceutical containing phenylethylamine, phycocyanins, mycosporine-like aminoacids and aphanizomenon flos aquae-phytochrome on the learning and memory ability, the oxidative status and cerebral erythropoietin and its receptor EPO/EPOR system in prematurely senescent (PS) mice. A total of 28 PS mice, selected according to a prior T-maze test, and 26 non-prematurely senescent mice (NPS) mice were chosen. PS animals were divided into 3 groups and followed for 4 weeks: A) normal chow diet; B) added with Klamin® at 20 mg/kg/day (low dose); C) added with Klamin® at 100mg/kg/day (high dose). A further group of NPS mice given either normal food (group D) or high dose Klamin® (group E) was also considered. The behavioral procedures of spatial learning ability (Morris test) showed that PS mice had significantly longer learning time as compared to their NPS counterpart (p>0.01), but this effect was prevented especially in mice supplemented with high-dose Klamin® (p>0.05) which improved performances in NPS mice (p>0.05). High-dose Klamin® supplementation restored the depleted total thiol concentration in the brain observed in PS mice while normalizing their increased malonildialdehyde level (p>0.05). Moreover, the high-dosage only caused a significant upregulation of EPO/EPOR system both in PS and in NPS animals (p>0.05). Taken together, these data suggest that this specific alga Klamath extract has considerable antioxidant and adaptogenic properties, also through a stimulatory effect of cerebral EPO/EPO system


Keywords

erythropoietin;brain cognitive impairment;oxidative stress;phycocyanins;prematurely senescent mice


References

Supporting Agencies



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