Impact of IL-18 on inflammation

D. Tripodi; G. Maccauro; A. Anogeianaki; M.L. Castellani; F. Pandolfi; P. Felaco; E. Toniato; M.A.De Lutiis; M. Fulcheri; S.; R. Galzio; V. Salini; A. Caraffa; P. Antinolfi; I. Frydas; G. Sabatino; Y.B. SHAIK-DASTHAGIRISAHEB

doi:10.54517/jbrha6203

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Impact of IL-18 on inflammation

Article ID: 6203
Vol 25, Issue 1, 2011

DOI: https://doi.org/10.54517/jbrha6203

Received: 8 April 2011; Accepted: 8 April 2011; Available online: 8 April 2011; Issue release: 8 April 2011

Abstract

IL-18 is produced by many cell types, such as Kupffer cells, keratinocytes, macrophages, dendritic cells, and activated T cells stimulated by LPS. It is an important regulator of both innate and acquired immune responses. IL-18 plays a central role in rheumatoid arthritis since the T cells and macrophages that invade the synovial. These finding support a role for IL-18 in inflammation, allergy and immune diseases

Keywords

interleukin-18;lymphocytes;immunoregulation;autoimmunity;inflammation

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