Implant surface activates fibroblasts: an in vitro study

P. Avvantaggiato, A. Piva, A. Pellati, G. Beltramini

Article ID: 6102
Vol 34, Issue 1S2, 2020
DOI: https://doi.org/10.54517/jbrha6102
Received: 10 March 2020; Accepted: 10 March 2020; Available online: 10 March 2020; Issue release: 10 March 2020

Abstract

Titanium (Ti) is that the most generally used material for dental, orthopedic and maxillofacial purposes thanks to its excellent biocompatibility and mechanical properties. Several data suggest that prosthesis anchorage to bone and soft tissue are often modulated by surface characteristics. Fibroblasts are the soft tissues cells concerned in producing extracellular matrix and collagen and their tight connection to implant neck is of paramount importance in preventing peri-implant infection. The aim of this work is to grow Human Fibroblast (HFb) for seven days in wells containing (or not) dental implants. The expression levels of some adhesion and traction-resistance related genes (COL11A1, COL2A1, COL9A1, DSP, ELN, HAS1, and TFRC) were analyzed using Polymerase Chain Reaction. Our results demonstrated that several genes encoding for extracellular matrix proteins are activated so giving more insight to the comprehension of the mechanism of cell to surface adhesion.


Keywords

titanium;implants;fibroblast;gene;expression


References

Supporting Agencies



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