Collagenated heterologous cortico-cancelleus bone mix stimulated dental pulp derived stem cells

G. Beltramini; A. Russillo; C. Baserga; A. Pellati; A. Piva; V. Candotto

doi:10.54517/jbrha6098

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Collagenated heterologous cortico-cancelleus bone mix stimulated dental pulp derived stem cells

G. Beltramini, A. Russillo, C. Baserga, A. Pellati, A. Piva, V. Candotto

Article ID: 6098
Vol 34, Issue 1S2, 2020

DOI: https://doi.org/10.54517/jbrha6098

Received: 10 March 2020; Accepted: 10 March 2020; Available online: 10 March 2020; Issue release: 10 March 2020

Abstract

Collagenated heretologous cortico-cancelleus bone mix (CHCCBM) is largely employed in maxillary and dental surgery for regeneration procedures, and is similar to human bone from chemical and physical point of view and promotes osteogenesis. In order to get more inside how this biomaterial induces osteoblast gene expression to promote bone formation, the mRNA levels of bone related genes were compared in human osteoblasts and dental pulp stem cells, using real time RT-PCR. The obtained results demonstrated that CHCCBM enhance stem cells differentiation and deposition of matrix by the activation of osteoblast related genes SP7, FOSL1 and SPP1.

Keywords

bone;dental pulp;stem cells;gene expression;osteoblast differentiation

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