Inhibitory effects of different lactobacilli on Candida albicans hyphal formation and biofilm development

C. F. Orsi, C. Sabia, A. Ardizzoni, B. COLOMBARI, R. G. Neglia, S. Peppoloni, G. Morace, E. Blasi

Article ID: 5956
Vol 28, Issue 4, 2014
DOI: https://doi.org/10.54517/jbrha5956
Received: 8 January 2015; Accepted: 8 January 2015; Available online: 8 January 2015; Issue release: 8 January 2015

Abstract

The aim of this study was to investigate the effects of different species of Lactobacilli on hyphal formation and biofilm development by the opportunistic fungal pathogen Candida albicans. We employed 4 different Lactobacillus species, namely L. rhamnosus, L. acidophilus, L. plantarum and L. reuteri, and 2 C. albicans strains, the reference DAY286 and its isogenic hwp1/hwp1 mutant, the FJS24 strain. As assessed by morphological analysis and quantitative colorimetric assays, Lactobacillus crude filtrate supernatant fluids (CFSF) affected Candida, impairing both hyphal formation and biofilm production. The CFSF-mediated phenomenon occurred in a dilution- and time-dependent manner and was consistently observed, irrespective of the C. albicans HWP1 genotype.


Keywords

Candida albicans;Lactobacillus;probiotics;hypha;biofilm;hyphal wall protein 1


References

Supporting Agencies



Copyright (c) 2014 C. F. Orsi, C. Sabia, A. Ardizzoni, B. COLOMBARI, R. G. Neglia, S. Peppoloni, G. Morace, E. Blasi




This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).