Increased risk of osteoporosis in postmenopausal women with type 2 diabetes mellitus: a three-year longitudinal study with phalangeal QUS measurements

C. Neglia, N. Agnello, A. Argentiero, G. Chitano, G. Quarta, I. Bortone, G. Della Rosa, A. Caretto, A. Distante, A. Colao, C. Di Somma, A. Migliore, R. S. Auriemma, P Piscitelli

Article ID: 5955
Vol 28, Issue 4, 2014
DOI: https://doi.org/10.54517/jbrha5955
Received: 8 January 2015; Accepted: 8 January 2015; Available online: 8 January 2015; Issue release: 8 January 2015

Abstract

Type 2 diabetes mellitus (T2DM) is associated with a higher risk of fractures even in presence of normal or increased bone mineral density. The purpose of this three-year longitudinal study was to evaluate the risk of osteoporotic fractures by assessing the changes of Quantitative Ultrasound (QUS) parameters in a group of postmenopausal women with type 2 diabetes mellitus (T2DM) compared with non-diabetic controls. The measurements were taken on a group of 18 postmenopausal women affected by T2DM and 18 healthy age-matched controls, aged 55-70 years, referring to the Osteolab laboratory at the ISBEM Research Institute (Brindisi, Italy) between 2009 and 2013. Subjects had baseline and 3-year follow-up measurements with phalangeal QUS carried out by a DBM Sonic Bone Profiler 1200 (Igea®); medical history, current drug therapies and risk factors for fractures were recorded for each patient. The analyzed phalangeal QUS parameters were Amplitude-Dependent Speed of Sound (AD-SoS), Bone Transmission Time (BTT), Fast Wave Amplitude (FWA) and Signal Dynamic (SDy). At the baseline visit we found no statistically significant difference between T2DM and non-diabetic patients when looking at phalangeal QUS parameters. At the three-year follow-up visit, a significantly higher decrease of both BTT (P<0.001) and AD-SoS (P<0.001) parameters was found in the T2DM group. On the contrary, the decrease of FWA was significantly higher in non-diabetic controls (P<0.001). Our data confirm the ability of phalangeal QUS to detect differences in the risk of osteoporotic fractures in T2DM postmenopausal women compared to non-diabetic controls. The study suggests that T2DM women present a higher cortical porosity and increased trabecular bone density compared to non-diabetic controls, respectively shown by the higher decrease of both AD-SoS and BTT and the lower decrease of FWA.


Keywords

osteoporosis;quantitative ultrasound;Type 2 diabetes


References

Supporting Agencies



Copyright (c) 2014 C. Neglia, N. Agnello, A. Argentiero, G. Chitano, G. Quarta, I. Bortone, G. Della Rosa, A. Caretto, A. Distante, A. Colao, C. Di Somma, A. Migliore, R. S. Auriemma, P Piscitelli




This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).