Comparative study on CT perfusion parameters of different types of lung cancer before and after chemoradiotherapy

Abstract

The aim of this paper was to observe the changes in computed tomography (CT) perfusion parameters of patients with lung cancer in early stage before and after chemoradiotherapy. Twenty-five previously treated lung cancer patients underwent a first CT perfusion scan and then a following one before the second course of chemotherapy. CT images of the fourth course of treatment were compared with the initial images. The cases were divided into a remission group and a non-remission group according to Response Evaluation Criteria In Solid Tumors (RECIST). Blood flow (BF), blood volume (BV), Patlak permeability Surface (PS) and Pallak blood volume (PBV) in the different groups were respectively compared before and after treatment. In addition, SPSS17.0 was applied for statistical analysis. P less than 0.05 signified that the difference had statistical meaning. CT perfusion parameters were all found to be changed compared to before the treatment. BV and PBV parameters decreased twice. BV and PBV parameters in the non-remission group showed an increasing trend. The difference before and after the treatment of these parameters had the highest statistical significance, as well as the difference of remission rate of PBV increasing group and decreasing group. Through the contrasting χ2 test of remission rate of BV and PBV, it was found that the remission rate of the BV increasing group and the decreasing group had no statistical difference; the remission rate in the PBV decreasing group was higher than the increasing group. All the findings suggest that the change in size of the damaged tissue had no statistical meaning in the early stage of CT perfusion parameter change; CT perfusion parameter of the remission group in the early stage after chemotherapy decreased while the non-remission group increased; the change of BV and PBV was significant.