Relationship between serotonin and mast cells: inhibitory effect of anti-serotonin

S. K. Kritas, A. Saggini, G. Cerull, A. Caraffa, P. Antinolfi, A. Pantalone, M. Rosati, M. Tei, A. Speziali, R. Saggini, P. Conti

Article ID: 5917
Vol 28, Issue 3, 2014
DOI: https://doi.org/10.54517/jbrha5917
Received: 9 October 2014; Accepted: 9 October 2014; Available online: 9 October 2014; Issue release: 9 October 2014

Abstract

Serotonin (5-HT) is an important neurotransmitter that acts in both central and peripheral nervous system, and has an impact on cell proliferation, migration and apoptosis. 5HT exerts its effects via several receptors. Treatment with anti-5-HT receptors diminish the severity of contact allergy in experimental animals, an effect mediated by mast cells; while an agonist reduces the stress level and relieves pruritus in patients with atopic dermatitis. Mast cells are important for both innate and adaptive immunity and they are activated by cross-linking of FceRI molecules, which are involved in the binding of multivalent antigens to the attached IgE molecules, resulting in a variety of responses including the immediate release of potent inflammatory mediators. Serotonin is present in murine mucosal mast cells and some authors reported that human mast cells may also contain serotonin, especially in subjects with mastocytosis. Here we report the interrelationship between mast cells, serotonin and its receptor inhibitor.


Keywords

serotonin;5-HT;mast cells;inflammation;brain;immunity


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Supporting Agencies



Copyright (c) 2014 S. K. Kritas, A. Saggini, G. Cerull, A. Caraffa, P. Antinolfi, A. Pantalone, M. Rosati, M. Tei, A. Speziali, R. Saggini, P. Conti




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