Interrelationship between IL-3 and mast cells

S. K. Kritas, A. Saggini, G. Cerulli, A. Caraffa, A. Pantalone, R. Saggini, S. Frydas, M. Rosati, M. Tei, A. Speziali, F. Pandolfi, P. Conti

Article ID: 5892
Vol 28, Issue 1, 2014
DOI: https://doi.org/10.54517/jbrha5892
Received: 8 April 2014; Accepted: 8 April 2014; Available online: 8 April 2014; Issue release: 8 April 2014

Abstract

It is well established that mast cells, which are found in the tissues in the proximity of small blood vessels and post-capillary venules, play a key role in the early phase of IgE-mediated allergic reactions. A greatly expanded understanding of the biology of IL-3 has emerged since the early 1980s. IL-3 is a specific factor that stimulates the growth of hematopoietic stem and progenitor cells of a variety of lineages and can promote the proliferation of certain classes of lymphocytes distinct from those that are dependent on IL-2. IL-3 has been identified among the most important cytokines for regulation of mast cell growth and differentiation, migration and effector function activities of many hematopoietic cells. IL-3 termed multi colony-stimulating-factor (multi-CSF) or mast cell growth factor (MCGF) is a haematopoietic growth factor which stimulates the formation of colonies for erythroid, megakaryocytic, granulocytic and monocytic lineages. It is predominantly produced by activated T cells, natural killer (NK) cells and mast cells and supports the growth-promoting effects of SCF on mast cell precursors. IL-3 causes severe hypersensivity reactions and plays a pivotal role in exacerbating the inflammatory response in vivo. Here we report the interrelationship between IL-3 and mast cells.


Keywords

Interleukin-3;mast cells;inflammation


References

Supporting Agencies



Copyright (c) 2014 S. K. Kritas, A. Saggini, G. Cerulli, A. Caraffa, A. Pantalone, R. Saggini, S. Frydas, M. Rosati, M. Tei, A. Speziali, F. Pandolfi, P. Conti




This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).