THE INFLUENCE OF CARBON MONOXIDE ON THE SECRETION OF MELATONIN BY PINEALOCYTES MEASURED IN VITRO

M Romerowicz-Misielak, O Kusak, A Koziorowska, F Przekop, M Koziorowski

Article ID: 5790
Vol 29, Issue 2, 2015
DOI: https://doi.org/10.54517/jbrha5790
Received: 9 July 2015; Accepted: 9 July 2015; Available online: 9 July 2015; Issue release: 9 July 2015

Abstract

Photoperiod is considered the most important factor entraining the circannual physiological rhythms through changing circadian patterns of melatonin (MEL) secretion from the pineal gland. The pineal gland of mammals does not respond directly to light but is controlled by light via neuronal phototransduction originating in the retina. In accordance with humoral phototransduction hypothesis, the aim of this study was to determine whether an increased concentration of CO, as a carrier of a light signal in pineal cell culture, affects the synthesis of melatonin. This study demonstrates that a commonly used carbon monoxide donor (CORM-2) markedly stimulated melatonin release from pineal cells incubated in vitro in a time-dependent manner, but the mechanism whereby CO modulates MEL release needs to be further explored.


Keywords

melatonin;carbon monoxide;pinealocytes in vitro culture


References

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