CROSSTALK BETWEEN VITAMIN B AND IMMUNITY

E Spinas, A Saggini, S K Kritas, G Cerulli, A Caraffa, P Antinolfi, A Pantalone, A Frydas, M Tei, A Speziali, R Saggini, F Pandolfi, P Conti

Article ID: 5789
Vol 29, Issue 2, 2015
DOI: https://doi.org/10.54517/jbrha5789
Received: 9 July 2015; Accepted: 9 July 2015; Available online: 9 July 2015; Issue release: 9 July 2015

Abstract

Vitamin B1 (thiamin) is considered to be the oldest vitamin and in 1936 R.R. Williams and colleagues determined its chemical structure and were able to synthesize this vitamin. Vitamin B1 influences pro-apoptotic proteins, mitochondrial membrane potential, cytochrome C release, protein kinases, p38-MAPK, suppresses oxidative stress-induced NF-kappaB and has anti-inflammatory properties. Deficiency of vitamin B1 may cause beriberi, dysfunction of the nervous system, neuroinflammation, T cell infiltration, chemokine CCL2 activation, over expression of proinflammatory cytokines, such as IL-1, TNF, IL-6, and arachidonic acid products, and induces expression of CD40 by the microglia and CD40L by astrocytes which provoke the death of neurons. Here we report the relationship between vitamin B complex and immunity.


Keywords

vitamin;immunity;inflammation;cytokine


References

Supporting Agencies



Copyright (c) 2015 E Spinas, A Saggini, S K Kritas, G Cerulli, A Caraffa, P Antinolfi, A Pantalone, A Frydas, M Tei, A Speziali, R Saggini, F Pandolfi, P Conti




This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).