Periprosthetic osteolysis: a narrative Article

A. Marmotti, D. Messina, A. Cykowska, C. Beltramo, E. Bellato, D. Colombero, G. Agati, L. Mangiavini, M. Bruzzone, F. Dettoni, G.M. Peretti, F. Castoldi

Article ID: 5666
Vol 34, Issue 4S3, 2020
DOI: https://doi.org/10.54517/jbrha5666
Received: 8 September 2020; Accepted: 8 September 2020; Available online: 8 September 2020; Issue release: 8 September 2020

Abstract

Periprosthetic osteolysis is still one of the major limitations of prosthetic joints longevity. The process of this "silent" iatrogenic disease involves both mechanical and biological factors that initiate a local immune response in the periprosthetic tissue that eventually lead to implant loosening and failure. There are many causes of the primary aseptic loosening inside the periprosthetic microenvironment, but the most important elements are the wear debris and the cell-particle interactions. Together with implant position, micromotion, bearings, joint fluid pressure, and increased load on the joints drive the pathogenesis of the disease. This narrative Article aims to summarise recent studies describing the biological and mechanical factors in the pathogenesis of osteolysis and some of the current pharmacological attempts to "rescue" a failing implant.


Keywords

periprosthetic osteolysis;growth factors;RANK-RANKL;osteoimmunology


References

Supporting Agencies



Copyright (c) 2020 A. Marmotti, D. Messina, A. Cykowska, C. Beltramo, E. Bellato, D. Colombero, G. Agati, L. Mangiavini, M. Bruzzone, F. Dettoni, G.M. Peretti, F. Castoldi




This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).