The effects of collagenase of Clostridium Histolitycum (CCH) in Dupuytrens disease: a histological study on cell mediated mechanisms that allow enzymatic fasciotomy

M. Passiatore; R.De Vitis; M. Saracco; C. Brunelli; F. Castri; G. Taccardo

doi:10.54517/jbrha5650

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The effects of collagenase of Clostridium Histolitycum (CCH) in Dupuytrens disease: a histological study on cell mediated mechanisms that allow enzymatic fasciotomy

M. Passiatore, R.De Vitis, M. Saracco, C. Brunelli, F. Castri, G. Taccardo

Article ID: 5650
Vol 34, Issue 4S3, 2020

DOI: https://doi.org/10.54517/jbrha5650

Received: 8 September 2020; Accepted: 8 September 2020; Available online: 8 September 2020; Issue release: 8 September 2020

Abstract

Dupuytren Disease is a benign fibromatosis of palmar fascia of the hand, whose pathophysiology is not completely understood. The present study is intended to provide a description of the effects of Collagenase of Clostridium Hystoliticum (CCH) into an injected cord of Dupuytren. Our experimental study wanted to evaluate the histological effects of injection of CCH in the first 24 hours, without manipulating the specimens. Materials and methods: Surgical specimens were injected with CCH, and then fixed in formalin every six hours, up to 24 hours. Those specimens were compared to control specimen (non-injected), fixed and analyzed at the same times. Results: In the injected specimens, the number of CD68 positive cells increased into and outside the cords compared to non injected specimens, within the same time from the surgical removal. Conclusion: CCH has a proinflammatory activity and provokes a short ray chemotactic action on white blood cells. The lysis of the cord induced by CCH stimulates the inflammatory response. The role of the inflammatory infiltration deserves to be investigated in a more accurate way, preferably by using in vivo studies.

Keywords

collagenase clostridium histolyticum;dupuytren’s disease;enzymatic fasciotomy;cell-mediated mechanisms;histology

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Medical Genetics, University of Torino Medical School, Italy

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2025-02-01

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