Magnesium alginate in patients with laryngopharyngeal reflux

G. Ciprandi, V. Damiani, F.M. Passali, A. Crisanti, G. Motta, D. Passali

Article ID: 5542
Vol 35, Issue 1S2, 2021
DOI: https://doi.org/10.23812/21-1supp2-12
Received: 11 March 2021; Accepted: 11 March 2021; Available online: 11 March 2021; Issue release: 11 March 2021

Abstract

Laryngopharyngeal reflux (LPR) is a common disease caused by the leaking beck of gastric material out of the esophagus. The main symptoms are dysphonia, dysphagia, and cough. There is an established use of proton pump inhibitors (PPI) in patients with suspected LPR in common practice. This habit is translated by the standard strategy to use PPI in treating patients with gastroesophageal reflux. However, PPI can not wholly inhibit all types of reflux and are burden by adverse effects. Alginate, a derivative from algae, is devoid of side effects and effectively counteracts gastric material reflux forming a foaming gel in the stomach. The current study enrolled 100 outpatients with LPR. Alginate treatment was administered for two months. Patients underwent four visits (at baseline and 15, 30, and 60 days after treatment). A visual analog scale assessed the perception of dysphonia, dysphagia, and cough. Alginate significantly (p<0.0001) reduced all parameters. Therefore, the current study demonstrated that magnesium alginate was effective and safe in LPR treatment.


Keywords

laryngopharyngeal reflux;magnesium alginate;dysphagia;dysphonia;cough


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