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Oxidative stress: general aspects and metabolic mechanisms
Vol 36, Issue 1S2, 2022
Abstract
Oxidative stress is characterized by the imbalance between production and accumulation of oxidants and the ability to detoxify these reactive products. Reactive oxygen species (ROS) and free radicals have a direct damaging effect on cellular functions and are involved in the pathogenesis of several diseases, including atherosclerosis, chronic obstructive pulmonary disease (COPD), diabetes, Alzheimer’s disease and cancer. Recently, research has focused on the possible beneficial role of antioxidant treatments against oxidative stress-related diseases. However, their efficacy and mechanisms of action are still debated. This review aims to clarify the mechanisms underlying oxidative stress and the development and progression of several oxidative stress-related diseases.
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Copyright (c) 2022 R. Giancaspro, M. Cassano, M. Gelardi
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy