The bad relationship, osteo-decay and diabetes type 2 searching for a link: a literature review

C Gargiulo Isacco; AD Inchingolo; KD Nguyen Cao; G Malcangi; G Paduanelli; V Pham Hung; T Tran Cong; IR Bordea; A Scarano; A Laforgia; G Marinelli; L Limongelli; F Inchingolo; F Lorusso; AM Inchingolo; G Dipalma

doi:10.23812/21-2supp1-26

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Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

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2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

The bad relationship, osteo-decay and diabetes type 2 searching for a link: a literature review

C Gargiulo Isacco, AD Inchingolo, KD Nguyen Cao, G Malcangi, G Paduanelli, V Pham Hung, T Tran Cong, IR Bordea, A Scarano, A Laforgia, G Marinelli, L Limongelli, F Inchingolo, F Lorusso, AM Inchingolo, G Dipalma

Article ID: 5472
Vol 35, Issue 2S1, 2021

DOI: https://doi.org/10.23812/21-2supp1-26

Received: 9 May 2021; Accepted: 9 May 2021; Available online: 9 May 2021; Issue release: 9 May 2021

Abstract

The diabetes and osteoporotic metabolic diseases are characterized by a wide prevalence of the population worldwide and correlated to alteration of the bone tissues. Several cofactors could influence the clinical course and the biochemistry of the pathologies such as human microbiome, nutrition characteristics, gut microbiota activity and interactions with vitamin K and D across IGF/GH and TP53 signaling pathways and the glucose/energy as mechanism for bone tissue health. Moreover, also the calories and sugar consumption seem to be correlated to an increased inflammatory state with several consequences for hematopoiesis and host tissues response. The aim of the present literature review was to highlight the role of osteoporotic diseases and diabetes type 2 link for the bone metabolism. The literature cases showed that a correlation between bone-gut-kidney-heart-CNS-Immunity crosstalk seems to be linked with bone metabolism and health regulation. Moreover, also the aging process could represent a valuable co-factor for the sustaining of the metabolic disorders upon a multi-systemic level.

Keywords

ATP;Diabetes type 1-2;IGF-1-2 PT53;ROS;Rank-l;Wnt;ageing;bone marrow;central nervous system;enteric nervous system;mTOR;mesenchymal stem cells;metabolic syndrome;mitochondria;osteoblasts;receptor activator NF kappa B ligand (NFκB-RANK);telomere/telomerasee

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Copyright (c) 2021 C Gargiulo Isacco, AD Inchingolo, KD Nguyen Cao, G Malcangi, G Paduanelli, V Pham Hung, T Tran Cong, IR Bordea, A Scarano, A Laforgia, G Marinelli, L Limongelli, F Inchingolo, F Lorusso, AM Inchingolo, G Dipalma

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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