Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.
Gabapentin and healthy gingival mucosa
Vol 36, Issue 2S1, 2022
Abstract
Gabapentin is a drug used to treat postoperative pain with antihyperalgesic properties and a unique mechanism of action, which differentiates it from other commonly used drugs. In our study fragments of gingival tissue of healthy volunteers were collected during operation. Gene expression of 29 genes was investigated in gingival fibroblasts cell culture treated with gabapentin, compared with untreated cells. Of the different chemokines and interleukins studied only 10 were statistically significant (CCL1, CCR1, CCR4, CCR5, CCR6, ILI1A, ILI1B, IL5, IL6R, TNFSF10). Gabapentin causes gingival hyperplasia in a limited number of patients by increasing expression of cytokines. This group of patients have probably a genetic background. Since or sample derived from healthy patients, we do not see an increase of cytokine expression. Additional studies are needed to better understand the interaction between gabapentin and gingival hyperplasia.
Keywords
References
Supporting Agencies
Copyright (c) 2022 M.T Miele, E Qorri, X Borshi, D Mucchi, V Candotto
This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).
Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy