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AF1q gene polymorphism proteomic markers in herpes zoster-infected leukemia patients
Vol 33, Issue 2, 2019
Abstract
The present study investigated two potential AF1q gene polymorphism proteomic markers in patientswith both leukemia and herpes zoster. A total of 40 individuals were randomly divided into two groups:Group A consisted of herpes zoster acute phase leukemia patients and Group B of healthy volunteers.Two polymorphisms, one in the promoter area and one in exon 1 of the AF1q gene were detected bypolymerase chain reaction (PCR) - restriction fragment length polymorphism (RFLP). BbvI and MseIdigestion of each AF1q gene polymorphism PCR amplicon revealed three distinct genotypes for eachpolymorphism. Proteomic results were extracted by iTraq. These results suggest that AF1q is involvedin the pathogenesis of leukemia combined with herpes zoster.
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Supporting Agencies
Copyright (c) 2019 X. Cheng, SL. Zhao, HM. Zhang
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy