Changes in postprandial serum fibroblast growth factor 19 in newly diagnosed type-2 diabetic patients and the clinical significance

Abstract

The present study aims to investigate changes in serum fibroblast growth factor 19 (FGF19) levelstwo hours after oral use of 75 g of glucose in newly diagnosed type-2 diabetic patients, and explore itsinfluence factors. Fifty newly diagnosed type-2 diabetic patients, admitted to our hospital from January2015 to December 2015, were randomly enrolled in the present study (T group), while 50 age- and gendermatchedsubjects, who presented with normal physical examination results were enrolled in the controlgroup. All subjects underwent oral glucose tolerance test (OGTT). Serum FGF19 levels at two hoursafter sugar use were compared, and the related influence factors of serum FGF19 were determined.The difference between the two groups was not statistically significant (P>0.05). The comparison ofrelated indexes after OGTT revealed that serum FGF19 levels were lower in the T group (198.06 pg/ml, range: 120.03-346.46 pg/ml) than in the control group (222.27 pg/ml, range: 126.92-382.62 pg/ml),but the difference was not statistically significant (P>0.05). Among these influence factors, postprandialserum FGF19 level was positively correlated with LDL-C and postprandial blood glucose in the T group,while postprandial serum FGF19 level was positively correlated with HbA1c in the control group. Therewas no significant difference in postprandial serum FGF19 level between patients with type-2 diabetesmellitus and healthy subjects. LDL-C and postprandial blood glucose may be independent factors forserum FGF19 levels in type-2 diabetic patients, and there is a positive correlation among these.