Serum 25-hydroxy vitamin D levels in essential hypertension

T. Granato, E. Anastasi, V. Viggiani, F. Occhiuzzi, A. Angeloni, R. Gradini, M. Suppa

Article ID: 5320
Vol 32, Issue 6, 2018
DOI: https://doi.org/10.54517/jbrha5320
Received: 8 January 2019; Accepted: 8 January 2019; Available online: 8 January 2019; Issue release: 8 January 2019

Abstract

Vitamin D may have prognostic value in hypertension patients and, in addition to conventional biomarkers, could be a valuable tool for disease management. The aim of this study was to assess the association of vitamin D status in patients with essential hypertension and to evaluate its prognostic utility. Forty-eight consecutive patients (40 Caucasian and 8 Asian) aged between 30 and 80 years (mean 61.5, range 34-84 years), were enrolled in the study. The main exclusion criteria were age less than 18 years, kidney failure, onco-hematologic disease, hypo-hyperparathyroidism, osteoporosis, treatment with bisphosphonate or 25(OH) vitamin D supplementation. Of the 48 patients included in the study, hyperlipidemia was described in 28, diabetes type 2 in 8, and ischemic heart disease in 14. Serum electrolytes, calcium, sodium, and potassium concentrations were within normal range. Low 25(OH) vitamin D levels inversely correlated with essential hypertension values (p less than 0.001) were considered extremely significant. The determination of 25(OH) vitamin D levels in patients with essential hypertension could improve the research for possible underlying conditions, which should be managed meticulously according to current guidelines.


Keywords

hypertension;25(OH) vitamin D;biomarkers;diagnosis


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