Contributions of VSX1 gene to keratoconus

G. Kalasidou, I. Frydas, A. Kozei, P. Syrmakesi, E. Loukovitis, K. Sfakianakis, M. Balidis, Z. Zachariadis, P. Tranos, N. Kozeis, G. Anogeianakis

Article ID: 5305
Vol 32, Issue 6, 2018
DOI: https://doi.org/10.54517/jbrha5305
Received: 8 January 2019; Accepted: 8 January 2019; Available online: 8 January 2019; Issue release: 8 January 2019

Abstract

Keratoconus (KC) is a complex, genetically heterogeneous, multifactorial degenerative corneal disorder, with incidence of approximately 1 per 2000 of the population. KC follows an autosomal recessive or dominant pattern of inheritance and is, apparently, associated with genes which interact with environmental, genetic and/or other factors. The present report focuses on the VSX1 gene, for which there is general agreement that it is involved in KC and other corneal pathologies, and critically details the evidence for its involvement in KC.


Keywords

keratoconus;VSX1 gene;keratoconus risk factors;keratoconus comorbidities


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Supporting Agencies



Copyright (c) 2018 G. Kalasidou, I. Frydas, A. Kozei, P. Syrmakesi, E. Loukovitis, K. Sfakianakis, M. Balidis, Z. Zachariadis, P. Tranos, N. Kozeis, G. Anogeianakis




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