Influence of circadian rhythm on exhaled breath profiling by electronic nose

V. Liotino; S. Dragonieri; V. N. Quaranta; P. Carratu; T. Ranieri; O. Resta

doi:10.54517/jbrha5266

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Influence of circadian rhythm on exhaled breath profiling by electronic nose

V. Liotino, S. Dragonieri, V. N. Quaranta, P. Carratu, T. Ranieri, O. Resta

Article ID: 5266
Vol 32, Issue 5, 2018

DOI: https://doi.org/10.54517/jbrha5266

Received: 8 November 2018; Accepted: 8 November 2018; Available online: 8 November 2018; Issue release: 8 November 2018

Abstract

Electronic noses (e-noses) are a cheap and easy method for exhaled Volatile Organic Compound (VOC)-analysis which has shown its potential in several diseases. Before obtaining a full validation of these instruments in clinical settings, a number of methodological issues still have to be established. We aimed to investigate a potential influence of circadian variation on VOC-profile analyzed by an e-nose in healthy subjects. We enrolled 22 adults free of any known diseases. A sequence of exhaled breath samplings were performed on all participants at predetermined hours (7am, 12pm, 17pm, 23pm) and analyzed by an e-nose (Cyranose 320). According to Principal Component Analysis, significant circadian variations of the exhaled VOC-profile were shown for Principal Component (PC) 1 and 3. In detail, PC1 and PC3 values were significantly higher in the morning compared to the afternoon and evening (for all parameters p less than 0.05). Successive Linear Discriminant analysis confirmed the findings above. The daily variations in VOCs-profile, with the peak in the morning, could be relevant for future clinical applications, especially in the choice of optimal time for sampling patients.

Keywords

exhaled breath;volatile organic compounds;electronic nose;circadian rhythm

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