FROM NEW SCIENTIFIC KNOWLEDGE ON ROSACEA TO ITS POSSIBLE MEDICOLEGAL CONSEQUENCES

P VELLANTE; M AURIEMMA; P AMERIO; A CARNEVALE; C

doi:10.54517/jbrha5241

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

FROM NEW SCIENTIFIC KNOWLEDGE ON ROSACEA TO ITS POSSIBLE MEDICOLEGAL CONSEQUENCES

Article ID: 5241
Vol 32, Issue 4, 2018

DOI: https://doi.org/10.54517/jbrha5241

Received: 8 September 2018; Accepted: 8 September 2018; Available online: 8 September 2018; Issue release: 8 September 2018

Abstract

New scientific knowledge of rosacea hides possible medico-legal consequences. Indeed, the solid molecular basis surrounding rosacea exacerbation and progression has been shown among genetically prone people who are exposed to trigger factors, such as moderately hot temperatures associated with employment. If this is ignored in the phase of prevention, then progression of rosacea might lead to medico-legal consequences.

Keywords

rosacea;moderately hot temperatures;employment;medico-legal consequences

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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2025-02-01

Notice of Change in Publication Schedule

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Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

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