Pure red cell aplasia with t-cell large granular lymphocytic leukemia

G. Shi; C-M. Hu; Q. Yu; N. Yang; Z-S. Xue; B. Zhao; M. Guo; Y. Zheng

doi:10.54517/jbrha5173

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Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Pure red cell aplasia with t-cell large granular lymphocytic leukemia

G. Shi, C-M. Hu, Q. Yu, N. Yang, Z-S. Xue, B. Zhao, M. Guo, Y. Zheng

Article ID: 5173
Vol 32, Issue 3, 2018

DOI: https://doi.org/10.54517/jbrha5173

Received: 9 July 2018; Accepted: 9 July 2018; Available online: 9 July 2018; Issue release: 9 July 2018

Abstract

Pure red cell aplasia (PRCA) develops as a result of erythroid precursors failing to reach maturity in the bone marrow, which eventually leads to anemia. Here we present a case of a 64-year-old Asian male with a medical history of colorectal adenocarcinoma who had been treated with 6 cycles of oxaliplatin and capecitabine four years ago. The patient was diagnosed with PRCA and T-cell large granular lymphocyte leukemia.

Keywords

pure red cell aplasia;T-cell large granular lymphocytic leukemia;chemotherapy;colorectal adenocarcinoma

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Medical Genetics, University of Torino Medical School, Italy

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Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

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