IL-1 haplotype analysis in periodontal disease


Article ID: 5141
Vol 32, Issue 2, 2018
DOI: https://doi.org/10.54517/jbrha5141
Received: 9 May 2018; Accepted: 9 May 2018; Available online: 9 May 2018; Issue release: 9 May 2018

Abstract

Numerous studies have established statistical associations of the IL-1 gene cluster polymorphisms with various inflammatory diseases. Deriving from that, the present study was intended to determine whether single-nucleotide polymorphisms (SNPs) in these gene are also associated with periodontal disease in a Linkage disequilibrium analysis. This investigation also created two haplotype blocks, both consisting of two different SNPs. Recent theoretical analyses indicate that research with an interpretation of periodontal disease as a complex, oligogenic disorder, with IL-1 genetic variation contributes an important but not exclusive influence on disease risk. Further studies are needed to confirm these results and to understand the mechanisms behind the observed association between IL-1 SNPs and periodontal disease.


Keywords

periodontal disease;single nucleotide polymorphisms;Interleukin-1;genetic factors;haplotype analysis


References

Supporting Agencies



Copyright (c) 2018




This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).