EXPRESSION OF SIRT5 PROTEIN IN GASTRIC CANCER CELLS

ZP. Wu; HX. Fang

doi:10.23812/19-184-A

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EXPRESSION OF SIRT5 PROTEIN IN GASTRIC CANCER CELLS

ZP. Wu, HX. Fang

Article ID: 5061
Vol 33, Issue 6, 2019

DOI: https://doi.org/10.23812/19-184-A

Received: 24 May 2019; Accepted: 24 May 2019; Available online: 8 January 2020; Issue release: 8 January 2020

Abstract

The purpose of this paper was to investigate the dynamic trend of SIRT5 (Sirtuins 5) protein expression in gastric cancer cells, for which a hypoxic gastric cancer cell line was established. Afterward, the parental gastric cancer cell group and hypo group were designed, and the levels of related proteins and mRNAs were detected by using Western blot along with real-time quantitative fluorescence PCR (RT-PCR). The results showed that the expression of SIRT5 in hypoxic gastric cancer cells increased significantly, which could increase the phosphorylation level of c-MET (hepatocyte growth factor receptor) and promote the migration of gastric cancer cells. When the expression of SIRT5 protein was observed under hypoxic conditions, SIRT5 silencing significantly reduced the migration ability of MGC803/hypo cells. It could be predicted that SIRT5-mediated protein desuccinylation played an important role in promoting the migration of hypoxic gastric cancer cells. Therefore, the migration rate of gastric cancer cells could be affected by controlling the expression of SIRT5 protein, which provides a novel idea for the treatment of gastric cancer in the future.

Keywords

gastric neoplasms;SIRT5 protein;hypoxia tolerance;cell migration

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