Effect of dexmedetomidine on stress reactions and cellular immune function of patients in perioperative period following radial resection for rectal carcinoma

Abstract

The study aimed to assess the effects and the further mechanism of action of dexmedetomidine with regard to stress reactions and cellular immune function of patients during the perioperative period following radical resection for rectal carcinoma. A total of 36 patients with rectal carcinoma were selected for radical resection under general anesthesia. The patients were divided into two groups, namely an experimental and a control group. In the experimental group (dexmedetomidine group) 1 μg/ kg/bw dexmedetomidine was injected intravenously 10 min prior to the induction of general anesthesia, and then infusion was carried out at a rate of 0.2 μg·kg-1·h-1 for 30 min prior to the end of surgery. With regard to the control group, the same amount of normal saline (NS) was infused with the same method as the experimental group. Controlled intravenous analgesia was conducted following surgery to all of the patients. Regarding the effect of dexmedetomidine on the reaction of stress, a decrease of VAS scores was noted in the experimental group following extubation compared with the control group (P less than 0.05). Furthermore, a significant decrease in the consumption of morphine in the first 24 h was observed that was accompanied by a decrease of plasma cortisol levels at 6 and 24 h following surgery compared with the control group. The levels of IFN-γ/IL-10 in the experimental group were lower than those of the control group (P less than 0.05). The percentages of CD8+ and CD4+/CD8+ cells in the experimental group were increased compared with those of the control group (P less than 0.05). By infusing dexmedetomidine continuously, stress reactions during the perioperative period were significantly decreased, whereas the analgesic effects of opioid were increased