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Extreme hyperferritinemia in the pediatric emergency setting: haemophagocytic lymphohistiocytosis, macrophage activation syndrome, sepsis and more
Vol 36, Issue 1S1, 2022
Abstract
Ferritin plays an important role in modulating inflammation and is a significant marker in some life-threatening pathological conditions. Hemophagocytic lymphohistiocytosis (HLH), macrophage activation syndrome (MAS), sepsis, and the more recent multisystem inflammatory syndrome in children (MIS-C) share many clinical and laboratory aspects, including the increase in ferritin levels, so that they are considered hyperferritinemic syndromes. In the pediatric emergency setting, the finding of high ferritin levels if associated with fever requires considering these rare syndromes to start a timely therapy.
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Copyright (c) 2022 C. Scozzafava, S. Sestito, D. Concolino, A. Giannotta, M. Miraglia Del Giudice, G.F. Parisi, G. Ceravolo, C. Cuppari, L. Pensabene, D. Sutera, A. Spagnuolo, R. Gallizzi
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy