Molecular evaluation of tissue proteins in vivo during controlled orthodontic movement

M Matarese, M Manuelli, L Grassi, G Caldara, A Liguori, G Matarese, A Lucchese

Article ID: 4604
Vol 33, Issue 5, 2019
DOI: https://doi.org/10.23812/19-136-A
Received: 24 April 2019; Accepted: 24 April 2019; Available online: 8 November 2019; Issue release: 8 November 2019

Abstract

Orthodontic tooth movement determines a biological response of all the tissues surrounding the teeth to which force is applied. The aim of this study is to evaluate which ideal orthodontic force, at the biological level, arouses an acute inflammatory response on periodontal tissues, and the duration of the force in order to establish an ideal experimental model of dental movement. The periodontal ligament and the alveolar bone change abruptly due to the biochemical adaptive response, resulting in a re-organization of the intracellular and the extracellular matrix. There is a modification of the local vascularization which stimulates a cascade production, synthesis and the release of arachidonic acid, metabolites, proteins, such as cytokines, and growth factors. Every dentist can control and should know the above-mentioned mechanism. Moreover, the production of proteins by modulating the direction and the intensity of the force can be changed but, above all, the duration.


Keywords

molecular evaluation;orthodontic;tooth movements


References

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