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Mesenchymal stem cells and IL-37: a powerful combination
Vol 33, Issue 4, 2019
Abstract
Mesenchymal stem cells (MSCs) are able to exert immunomodulatory and anti-inflammatory actions. Thanks to these properties, MSCs may be a promising alternative approach for the treatment of inflammatory disease. Important cytokines involved in inflammation are those included in the IL-1 family. Interleukin-37 (IL-37) is one of the member able to suppress both innate and adaptive immunity. Recently, it was found that MSCs and their derivatives can modulate IL-37, and MSCs expressing IL-37 seem to have an enhanced therapeutic efficacy.
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Copyright (c) 2019 A. Gugliandolo, AL. Caraffa, C.E. Gallenga, S.K. Kritas, G. Ronconi, O. Trubiani, P. Conti, P.Di Emidio, E. Mazzon
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy