Effects of oxycodone hydrochloride on immune function and biochemical indexes in puerperas undergoing cesarean section

Abstract

The aim of this study was to investigate the effect of oxycodone on the immune function and biochemical parameters in puerpera undergoing cesarean section. The puerperas undergoing cesarean section were randomly divided into two groups, namely, the oxycodone hydrochloride group (group A) and the morphine group (group B). After the operation, patient controlled intravenous analgesia (PCIA) was used for medication. The analgesic effects at different time points, after 1 h, 2 h, 6 h, 12h, 24 h and 48 h, were recorded. The score of the numerical rating scale (NRS) of uterine contraction pain was evaluated. At the same time, peripheral blood was taken at different time points after analgesia (immediately after surgery, then 24 h, 48 h and 72 h after surgery). Th1 and Th2 cell levels and biochemical parameters were determined. Compared with the morphine group, the Th1 cell level in the oxycodone hydrochloride group was significantly increased at 24 h and 48 h after surgery (P<0.05). Th2 level was significantly increased compared to that of morphine at 24 h, 48 h and 72 h after surgery (P<0.05). The alanine aminotransferase (ALT) level and aspartate aminotransferase (AST) level in the oxycodone hydrochloride group were significantly decreased compared to that of the morphine group at 24 h after surgery. AST level in the oxycodone hydrochloride group was significantly increased compared to that of the morphine group at 72 h after surgery (P<0.05). The total bilirubin (TB) level was significantly increased in the oxycodone hydrochloride group compared to the morphine group at 24 h, 48 h and 72 h post-surgery (P<0.05). Compared with morphine, oxycodone can increase the level of Th1 and Th2 immune cells in peripheral blood in puerperas undergoing cesarean section, and has an increased effect on liver function, without causing abnormal liver function.