Effect of silver vitellinate, hyaluronic acid and sodium benzoate nasal spray after septoplasty

Abstract

The aim of the study was to evaluate the postoperative endoscopic score and the quality of life (QoL) in two groups of adults undergoing septoplasty with turbinoplasty and who were treated after surgery with a nasal spray containing silver vitellinate, hyaluronic acid and sodium benzoate, or saline solution alone. This single-blind randomized study was carried out on 54 patients (30 males, and 24 females, mean age 33.5±2.7 years) undergoing septoplasty and volumetric tissue reduction of inferior turbinates for nasal obstruction. All subjects underwent the Visual Analogue Scale (VAS) questionnaire and the nasal endoscopy score by Lund and Kennedy (LK) at baseline before surgery (T0), 15 days (T15) and 21 days (T21) after treatment. All subjects were randomized into 2 groups, the experimental arm, group I (GI), and the control arm, group II (GII). Patients were given the treatment, a nasal spray containing silver vitellinate, hyaluronic acid and sodium benzoate for group I and a saline solution alone (sodium chloride 0.9%) for group II. After therapy, better VAS and LK scores were found (P < 0.05) in the GI in GII. No patients reported adverse reactions or complications. Our findings suggest that silver vitellinate, hyaluronic acid and sodium benzoate nasal spray improved not only the endoscopic score, but also the quality of life (QoL) in the early postoperative period after septoplasty. In addition, the absence of adverse reactions or complications pointed out the tolerability and safety of the treatment.