Long non-coding RNA SNHG7 silencing confers protection against epithelial-mesenchymal transition in ovarian cancer cells via microRNA-34a-targeted EDG4 and the PI3K/AKT pathway

Y.C. Zhao; Y. Li

doi:10.23812/21-300-A

Publication Frequency

Quarterly since 2025

Journal Articles

Search scope

Journal Center

Asia Pacific Academy of Science Pte. Ltd. (APACSCI) specializes in international journal publishing. APACSCI adopts the open access publishing model and provides an important communication bridge for academic groups whose interest fields include engineering, technology, medicine, computer, mathematics, agriculture and forestry, and environment.

more

Volume Arrangement

2025

Vol 39, No 3 (2025)

Vol 39, No 2 (2025)

Vol 39, No 1 (2025)

Featured Articles

Macrophages in the pathogenesis of psoriasis and anti-psoriatic nanotherapies

Psoriasis is a common, chronic, and inflammatory skin disease. Macrophages account for about 61.3% of the inflammatory cells infiltrating psoriatic lesions. Modulating macrophage polarization, inhibiting their infiltration, and targeting the secretion of inflammatory factors and associated inflammatory pathways by these cells can alleviate psoriasis symptoms and inflammation. Moreover, nanomaterials as novel drug carriers, offer unique advantages such as large surface area, easy modification, high biocompatibility, good biodegradability, enhanced systemic adsorption, etc. Nanomaterials have great potential for efficient drug delivery and release, as well as improving therapeutic efficacy while reducing adverse effects. By systematically addressing the role of macrophages in psoriasis pathogenesis and the potential of nanomaterials in treating psoriasis through modulating macrophages, this review enhances our understanding of the disease mechanism and holds promise for novel therapeutic breakthroughs and advancements in the future treatment of psoriasis.

Long non-coding RNA SNHG7 silencing confers protection against epithelial-mesenchymal transition in ovarian cancer cells via microRNA-34a-targeted EDG4 and the PI3K/AKT pathway

Y.C. Zhao, Y. Li

Article ID: 4494
Vol 35, Issue 6, 2021

DOI: https://doi.org/10.23812/21-300-A

Received: 8 January 2022; Accepted: 8 January 2022; Available online: 8 January 2022; Issue release: 8 January 2022

Abstract

Long non-coding RNA small nucleolar RNA host gene 7 (lncRNA SNHG7) and microRNA-34a (miR-34a) have been implicated in ovarian cancer (OC) development. Furthermore, the binding of SNHG7 to miR-34a is widely recognized in numerous cancers. Therefore, our research intended to explore the specific mechanism of SNHG7 and miR-34a in OC. SNHG7, miR-34a, and endothelial differentiation gene (EDG) 4 expression in harvested OC tissues and cells were measured by RT-qPCR. Dual-luciferase reporter gene assay and RIP assay were implemented to assess the binding of SNHG7 to miR-34a, and of miR-34a to EDG4. Gain- and loss-of-function assays were implemented in OC cells, followed by scratch test and Transwell assay of cell migration and invasion, respectively. The epithelial-mesenchymal transition (EMT) and the PI3K/AKT pathway-related proteins were measured by Western blot analysis. SNHG7 and EDG4 were overexpressed, but miR-34a was poorly expressed in OC tissues and cells. miR-34a bound to SNHG7 and targeted directly EDG4, and SNHG7 activated the PI3K/AKT pathway in OC cells. Furthermore, SNHG7 or EDG4 silencing, miR-34a overexpression, or PI3K/AKT pathway bluntness diminished OC cell invasion, migration, and EMT. Collectively, SNHG7 downregulation repressed EMT of OC cells via miR-34a-targeted EDG4 and the PI3K/AKT pathway.

Keywords

Ovarian cancer;Long non-coding RNA SNHG7;microRNA-34a;EDG4;PI3K/AKT pathway;Epithelial-mesenchymal transition

References

Supporting Agencies

This site is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0).

Editor-in-Chief

Dr. Fabio Malavasi

Medical Genetics, University of Torino Medical School, Italy

Co-Editor-in-Chief

Prof. Marcello Iriti

Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy

Indexing & Archiving

News & Announcements

2025-02-01

Notice of Change in Publication Schedule

In addition to the first issue that has already been published by the original publisher, there will be four more issues released this year, with scheduled publication dates in March, June, September, and December respectively.

2025-01-21

Notice: Ownership Transfer of the Journal

Starting from Volume 39 Issue 2 (2025), the ownership of Journal of Biological Regulators and Homeostatic Agents (ISSN: 0393-974X (P); 1724-6083 (O)) will be transferred from Biolife Sas to Asia Pacific Academy of Science Pte. Ltd. As of 21 January 2025, authors should make submissions to the new journal system and follow the author guidelines. Asia Pacific Academy of Science Pte. Ltd. will take over the publication of manuscripts being processed.

More Announcements...