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EIF4E3 is an immune infiltration correlated prognosticator in colon cancer
Vol 35, Issue 5, 2021
Abstract
Colon cancer is a highly malignant gastrointestinal cancer, and genes in the tumor infiltrating cells and microenvironment are emerging as pivotal players in its development and prognosis. In this study, TIMER and StarBase tools were used to find whether EIF4E3 gene was downregulated in colon tissues, and whether lower expression of EIF4E3 was associated with poor prognosis in colon cancer patients, as well as to ascertain that EIF4E3 could regulate immune-related pathways by gene set enrichment analysis (GSEA). Using TIMER (Tumor Immune Estimation Resource) database and ImmuneCellAI tools, it was found that EIF4E3 expression was correlated with tumor immune infiltrates in colon cancer. The results identified EIF4E3 as an immune infiltrate-correlated prognosticator in colon cancer.
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Copyright (c) 2021 YQ. Guo, YZ. Jiang, CH. Chen, LJ. Wu, HJ, KS. Chen, JJ. Xia, ZY. Liu
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy