Elevated plasma il-8 concentration is related to severity of systemic inflammation in chronic spontaneous urticaria

A. Kasperska-Zajac, A. Grzanka, A. Damasiewicz-Bodzek, K. Bieniek, A. Skrzypulec-Frankel, K. Stencel-Gabriel, A. Sikora-Zydek

Article ID: 4431
Vol 31, Issue 4, 2017
DOI: https://doi.org/10.54517/jbrha4431
Received: 6 June 2022; Accepted: 6 June 2022; Available online: 6 June 2022; Issue release: 6 June 2022

Abstract

Chronic spontaneous urticaria (CSU) is associated with activation of acute phase response. Questions arise regarding its association with other inflammatory mediators. To determine plasma IL-8 concentration in CSU patients and its association with C-reactive protein (CRP) concentration, a nonspecific inflammatory marker of the disease activity, concentrations of plasma IL-8 and serum CRP were measured in CSU patients and compared with healthy controls. IL-8 and CRP concentrations were significantly higher in CSU patients as compared with the healthy subjects. In addition, there were significant differences in IL-8 and CRP concentrations between CSU patients with moderate-severe symptoms and the healthy subjects. Plasma IL-8 and serum CRP concentrations showed a significant correlation with urticaria activity score (UAS). Additionally, a significant positive correlation was observed between IL-8 and CRP concentrations. Up-regulations of IL-8 and its association with the marker of clinical and inflammatory activity suggest a role of this cytokine in the pathogenesis of CSU.


Keywords

IL-8;chronic spontaneous urticaria;acute phase response;C reactive protein


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