Association of BCL-2 with oxidative stress and total antioxidant status in pediatric acute lymphoblastic leukemia

I.M. Tahir; T. Iqbal; A. Jamil; M. Saqib

doi:10.54517/jbrha4398

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Association of BCL-2 with oxidative stress and total antioxidant status in pediatric acute lymphoblastic leukemia

I.M. Tahir, T. Iqbal, A. Jamil, M. Saqib

Article ID: 4398
Vol 31, Issue 4, 2017

DOI: https://doi.org/10.54517/jbrha4398

Received: 8 January 2018; Accepted: 8 January 2018; Available online: 8 January 2018; Issue release: 8 January 2018

Abstract

B-Cell Lymphoma protein-2 (BCL-2) is one of the most studied proteins with substantial regulatory potential for both apoptosis and autophagy. BCL-2 confer chemoresistance through influencing cancer pathophysiology. Serum level of lactate dehydrogenase (LDH) predicts increased anaerobic glycolysis and is associated with metabolic modulation in cancer cells. In the present research, the interplay of BCL-2, total oxidative status (TOS) and LDH was investigated in patients with acute lymphoblastic leukemia (ALL). The studied parameters, BCL-2 protein (p less than 0.001), TOS (p less than 0.001) and LDH (p less than 0.001) were significantly elevated in the ALL group compared to the normal group (N-group). However, the total antioxidant status (TAS) was reduced significantly (p less than 0.01) in ALL patients. In the ALL group, the TOS had significant negative correlation with TAS (p less than 0.01). Furthermore, non-significant positive correlations were found between BCL-2 and LDH, BCL-2 and TAS and LDH and TAS (each with; p>0.05). However, a negative non-significant correlation was observed between BCL-2 and TOS and LDH and TOS (each with; p<0.05)

Keywords

apoptosis;childhood leukemia;free radicals;lactate dehydrogenase (ldh);oxidative stress

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