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Colorectal cancer: an update on the effects of lycopene on tumor progression and cell proliferation
Vol 31, Issue 3, 2017
Abstract
Colorectal cancer (CRC) is one of the most common cancers worldwide. Various factors, including oxidative stress, where excessive productions of reactive oxygen species (ROS) and reactive nitrogen species (RNS) occur, contribute to its pathogenesis. Numerous studies have investigated the effect of antioxidant substances derived from food such as fruits and vegetables; however, data on Lycopene are still rare. Studies on HT-29 colorectal cancer cells and on animal models have shown that lycopene has effects on cell proliferation and on the progression of the CRC by interacting with various cellular signaling pathways. This analysis of the literature focused on the antioxidant effect of lycopene, a substance that is found in the tomato.
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Copyright (c) 2017 F. Carini, S. David, G. Tomasello, M. Mazzola, P. Damiani, F. Rappa, L. Battaglia, F. CAPPELLO, A. JURJUS, A.Gerges Geagea, R. Jurjus, A. Leone
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy