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CYCLOSPORINE–A AUGMENTS ENDOPLASMIC RETICULUM STRESS MARKERS AND EXPRESSION OF MATRIX PROTEIN mRNA
Vol 31, Issue 1, 2017
Abstract
Cyclosporine-A induces gingival overgrowth with disturbance in the homeostasis of cells and connective tissue proteins. Human gingival fibroblasts were cultured with cyclosporine A, and the expression of two vital endoplasmic stress markers and two prime matrix proteins (connective tissue growth factor (CTGF and periostin) were assessed by RT-PCR. We found that expression of Glucose-Regulated Protein 78 (GRP78/BIP) and CCAAT/enhancer binding protein, C/EBP homologous protein (CHOP) were significantly increased, along with CTGF and periostin, suggesting a role for these factors in gingival overgrowth
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Copyright (c) 2017 S R Rao, R Subbarayan, D M Girija
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Medical Genetics, University of Torino Medical School, Italy
Department of Biomedical, Surgical and Dental Sciences, University of Milan, Italy