EXPRESSIONS OF NDRG1, VEGF AND Ki-67 IN CONDYLOMA ACUMINATUM

Abstract

The objective of this study was to explore the expressions and significance of NDRG1 (N-mycdownregulated gene family 1), VEGF (vascular endothelial growth factor) and Ki-67 in lesions of CondylomaAcuminatum (CA). Immunohistochemistry was adopted to measure the expressions of NDRG1, VEGFand Ki-67 in 48 cases of CA and 18 normal skin controls. The positive rates of NDRG1, VEGF and Ki-67were 63. 83.33% (40/48), 93.75% (45/48) and 85.42% (41/48) in the CA tissues, and 27.78% (5/18), 94.44%(17/18) and 61.11% (11/18) in the controls, respectively. The intensities of the expressions of NDRG1,VEGF and Ki-67 in CA tissues were significantly higher than those in the controls. There were significantdifferences both in the positive rates and the expression intensities of NDRG1, VEGF and Ki-67 between thetwo groups (P <0.05). The Spearman’s Rank-Order Correlation analysis indicated that the expressions ofNDRG1 protein and VEGF protein were positively correlated by the Spearman’s Rank-Order Correlationanalysis (r = 0.346, P=0.016). For the CA tissues with high expressions of NDRG1 and VEGF, NDRG1 and VEGF influenced both the occurrence and development of CA.