Correlation between IL-6 and invasiveness of ectoderm cells of embryo in early pregnancy

X Y Jiang; T M Lu; W H Shu; H Y Zhou

doi:10.54517/jbrha4173

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Correlation between IL-6 and invasiveness of ectoderm cells of embryo in early pregnancy

X Y Jiang, T M Lu, W H Shu, H Y Zhou

Article ID: 4173
Vol 30, Issue 2, 2016

DOI: https://doi.org/10.54517/jbrha4173

Received: 6 June 2022; Accepted: 6 June 2022; Available online: 6 June 2022; Issue release: 6 June 2022

Abstract

This study aimed to explore the correlation between Interleukin-6 (IL-6) and invasiveness of ectoderm cells of embryo in early pregnancy, in order to further discuss whether IL-6 can enhance invasiveness of ectoderm cells. The study lays the foundation for determination of pathogenesis of some gestation period-related diseases. Differences in mRNA and protein expression of trophoblastic cell line JEG-3 cells in IL-6, matrix metalloproteinase-2 (MMP-2) and MMP-9 were analyzed; the regulating effect of different concentrations of IL-6 on invasive ability of trophoblast cells was studied by Transwell assay; the effect of IL-6 on proliferation of ectodermal cell line JEG-3 of embryo was analyzed by methyl thiazolyl tetrazolium (MTT) assay. The invasive number of JEG-3 cells incubated by IL-6 (10 ng/ml) was higher than that of the control group, and the difference had statistical significance (p < 0.05). Results of using MMT assay to detect the effect of IL-6 on proliferation of trophoblastic cell line JEG-3 showed that JEG-3 cells before and after processing had no significant difference from the control group (p >0.05). Therefore, IL-6 can enhance invasiveness of ectoderm cells of embryo through activation of MMP-2.

Keywords

ectoderm cells of embryo (trophoblast cells);IL-6;JEG-3;transwell experiment

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